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Literature summary for 1.2.1.104 extracted from

  • Pei, Y.; Tarun, A.S.; Vaughan, A.M.; Herman, R.W.; Soliman, J.M.; Erickson-Wayman, A.; Kappe, S.H.
    Plasmodium pyruvate dehydrogenase activity is only essential for the parasites progression from liver infection to blood infection (2010), Mol. Microbiol., 75, 957-971.
    View publication on PubMed
Search for more literature for 1.2.1.104

Localization

Localization Comment Organism GeneOntology No. Textmining
apicoplast the PDH E1a and E3 subunits colocalize with the FAS II enzyme FabI in the apicoplast of liver stages but are not significantly expressed in blood stages Plasmodium yoelii 20011
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + CoA + NAD+ Plasmodium yoelii
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 acetyl-CoA + CO2 + NADH
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 ?

Organism

Organism UniProt Comment Textmining
Plasmodium yoelii
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + CoA + NAD+
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 Plasmodium yoelii acetyl-CoA + CO2 + NADH
-
 ?

Synonyms

Synonyms Comment Organism
PDH
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 Plasmodium yoelii

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Plasmodium yoelii

General Information

General Information Comment Organism
malfunction deletion of the E1a or E3 subunit genes of Plasmodium yoelii PDH causes no defect in blood stage development, mosquito stage development or early liver stage development. However, the gene deletions completely block the ability of the e1alpha- and e3-deficient parasites to form exo-erythrocytic merozoites during late liver stage development, thus preventing the initiation of a blood stage infection Plasmodium yoelii
physiological function Plasmodium pyruvate dehydrogenase activity is only essential for the parasites progression from liver infection to blood infection. The sole role of PDH is to provide acetyl-CoA for FAS II. PDH subunits E1a and E3 subunits are not essential for either blood stage or mosquito stage development but are essential for late liver stage development Plasmodium yoelii