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Literature summary for 1.2.1.104 extracted from

  • Contreras Ndel, P.; Vasquez, C.C.
    Tellurite-induced carbonylation of the Escherichia coli pyruvate dehydrogenase multienzyme complex (2010), Arch. Microbiol., 192, 969-973.
    View publication on PubMed
Search for more literature for 1.2.1.104

Inhibitors

Inhibitors Comment Organism Structure
tellurite pyruvate dehydrogenase activity decreases by 81% after tellurite treatment (0.0005 mg/ml for 30 min) Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase) ?
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 ?
additional information Escherichia coli BW25113 the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase) ?
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Escherichia coli BW25113
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-

Oxidation Stability

Oxidation Stability Organism
pyruvate dehydrogenase activity decreases by 88% after H2O2 treatment (2.5 mM for 30 min) Escherichia coli

Purification (Commentary)

Purification (Comment) Organism
Ni2+-Sepharose column chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase) Escherichia coli ?
-
 ?
additional information the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase) Escherichia coli BW25113 ?
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 ?
pyruvate + CoA + NAD+
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 Escherichia coli acetyl-CoA + CO2 + NADH
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 ir
pyruvate + CoA + NAD+
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 Escherichia coli BW25113 acetyl-CoA + CO2 + NADH
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 ir

Synonyms

Synonyms Comment Organism
PDH complex
-
 Escherichia coli
pyruvate dehydrogenase complex the complex displays two distinct enzymatic activities: pyruvate dehydrogenase and tellurite reductase Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Escherichia coli
thiamine diphosphate
-
 Escherichia coli