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Literature summary for 1.2.1.104 extracted from

  • Yu, X.; Hiromasa, Y.; Tsen, H.; Stoops, J.K.; Roche, T.E.; Zhou, Z.H.
    Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains (2008), Structure, 16, 104-114.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in vivo there are 20-30 E1 molecules bound to each core of the mammalian PDC, the small binding domain of E2 in humans binds only to E1 Homo sapiens ?
-
?
pyruvate + CoA + NAD+
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Homo sapiens acetyl-CoA + CO2 + NADH
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?

Subunits

Subunits Comment Organism
heterotetramer x-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
pyruvate dehydrogenase E1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
Homo sapiens