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Literature summary for 1.2.1.104 extracted from

  • Sharma, N.; Okere, I.C.; Brunengraber, D.Z.; McElfresh, T.A.; King, K.L.; Sterk, J.P.; Huang, H.; Chandler, M.P.; Stanley, W.C.
    Regulation of pyruvate dehydrogenase activity and citric acid cycle intermediates during high cardiac power generation (2005), J. Physiol., 562, 593-603.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.1.104

Activating Compound

Activating Compound Comment Organism Structure
dobutamine increases pyruvate dehydrogenase complex activity Sus scrofa
additional information enzyme complex activity is increased with high workload and energy expenditure in the myocardium Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Sus scrofa 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa regulation of pyruvate dehydrogenase complex activity and citric acid cycle intermediates during high cardiac power generation, inhibition of fatty acid oxidation has a regulatory function, overview ?
-
 ?
pyruvate + CoA + NAD+ Sus scrofa
-
 acetyl-CoA + CO2 + NADH
-
 ir

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein regulation of pyruvate dehydrogenase complex activity through reversible phosphorylation Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 measurement of NADH/NAD+ and acetyl-CoA/CoA ratios, and citric acid cycle intermediates in blood and tissue, measurement of O2-uptake and fatty acid and glucose oxidation level Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulation of pyruvate dehydrogenase complex activity and citric acid cycle intermediates during high cardiac power generation, inhibition of fatty acid oxidation has a regulatory function, overview Sus scrofa ?
-
 ?
pyruvate + CoA + NAD+
-
 Sus scrofa acetyl-CoA + CO2 + NADH
-
 ir

Synonyms

Synonyms Comment Organism
PDH
-
 Sus scrofa
pyruvate dehydrogenase complex
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Sus scrofa