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Literature summary for 1.2.1.104 extracted from
- Some kinetic and regulatory properties of the pea mitochondrial pyruvate dehydrogenase complex (1987), Plant Physiol., 83, 306-310.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glyoxylate | competitive vs. pyruvate | Pisum sativum |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00008 | - |
thiamine diphosphate | whole enzyme complex | Pisum sativum | |
| 0.36 | - |
Mg2+ | whole enzyme complex | Pisum sativum | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Pisum sativum | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | can replace Mg2+ | Pisum sativum | |
| Mg2+ | absolute requirement | Pisum sativum | |
| Mn2+ | can replace Mg2+ | Pisum sativum | |
| additional information | no activation by other divalent cations, except Mg2+, Mn2+, Ca2+, Ni2+ | Pisum sativum | |
| Ni2+ | can replace Mg2+ | Pisum sativum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pisum sativum | - |
pea | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| pyruvate dehydrogenase complex composed of EC 1.2.4.1, EC 2.3.1.12, EC 1.8.1.4 | Pisum sativum |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Pisum sativum | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0513 | - |
assay with whole enzyme complex | Pisum sativum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetaldehyde + benzaldehyde | - |
Pisum sativum | (R)-phenylacetylcarbinol | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
values for pyruvate dehydrogenase complex: 35-50°C | Pisum sativum |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 15 | 50 | value for pyruvate dehydrogenase complex | Pisum sativum |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
irreversible inactivation | Pisum sativum |
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Release 2023.1 (January 2023)
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