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Literature summary for 1.2.1.10 extracted from

  • Rudolph, F.B.; Purich, D.L.; Fromm, H.J.
    Coenzyme A-linked aldehyde dehydrogenase from Escherichia coli. I. Partial purification, properties, and kinetic studies of the enzyme (1968), J. Biol. Chem., 243, 5539-5545.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
sulfhydryl compound requirement for reduced form Escherichia coli

General Stability

General Stability Organism
extremely unstable in absence of 2-mercaptoethanol Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Chloroethanol
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
CoA
-
Escherichia coli
0.013
-
acetyl-CoA
-
Escherichia coli
0.05
-
NAD+
-
Escherichia coli
0.1
-
NADH
-
Escherichia coli
1.5
-
acetaldehyde
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetaldehyde + CoA + NAD+ Escherichia coli
-
acetyl-CoA + NADH
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.11
-
-
Escherichia coli

Storage Stability

Storage Stability Organism
3°C, ammonium sulfate step of purification, several months Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaldehyde + CoA + NAD+
-
Escherichia coli acetyl-CoA + NADH
-
?
acetyl-CoA + NADH
-
Escherichia coli acetaldehyde + CoA + NAD+
-
r
additional information not benzaldehyde Escherichia coli ?
-
?
additional information not: chloral, formaldehyde, D,L-glyceraldehyde Escherichia coli ?
-
?
n-butyraldehyde + CoA + NAD+
-
Escherichia coli n-butyryl-CoA + NADH
-
r
propanal + CoA + NAD+
-
Escherichia coli propionyl-CoA + NADH
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
6.2 7.4 67% of maximal activity at pH 6.2, 79% of maximal activity at pH 7.4 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
CoA
-
Escherichia coli
NAD+
-
Escherichia coli