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Literature summary for 1.18.6.1 extracted from
- Structural basis for VO2+ inhibition of nitrogenase activity (A): 31P and 23Na interactions with the metal at the nucleotide binding site of the nitrogenase Fe protein identified by ENDOR spectroscopy (2008), J. Biol. Inorg. Chem., 13, 623-635.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| VO2+ | structural basis for VO2+ inhibition of nitrogenase activity, 31P and 23Na interactions with the metal at the nucleotide binding site of the nitrogenase Fe protein identified by ENDOR spectroscopy, vanadyl hyperfine couplings of VO2+-ATP and VO2+-ADP complexes in the presence of the nitrogenase Fe protein, overview | Klebsiella pneumoniae |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | nitrogenase Fe protein, the FeS cluster exhibits very little change upon MgATP binding, two bound nucleotides are believed to mediate the diverse, functionally essential structural rearrangements in the Fe protein | Klebsiella pneumoniae | |
| Mg2+ | required, the FeS cluster exhibits very little change upon MgATP binding | Klebsiella pneumoniae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| reduced ferredoxin + H+ + N2 + ATP | Klebsiella pneumoniae | - |
oxidized ferredoxin + H2 + NH3 + ADP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella pneumoniae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| reduced ferredoxin + H+ + N2 + ATP | - |
Klebsiella pneumoniae | oxidized ferredoxin + H2 + NH3 + ADP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | Kp2 structure analysis bound to Vo2+, ATP, and ADP, characterization of the metal-nucleotide coordination environment, overview | Klebsiella pneumoniae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Kp2 | - |
Klebsiella pneumoniae |
| nitrogenase Fe protein | - |
Klebsiella pneumoniae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | the FeS cluster exhibits very little change upon MgATP binding | Klebsiella pneumoniae | |
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