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Literature summary for 1.18.6.1 extracted from

  • Mortenson, L.E.; Thorneley, R.N.F.
    Structure and function of nitrogenase (1979), Annu. Rev. Biochem., 48, 387-418.
    View publication on PubMed
Search for more literature for 1.18.6.1

Inhibitors

Inhibitors Comment Organism Structure
C2H2 noncompetitive inhibitor of N2 reduction Azotobacter chroococcum
C2H2 noncompetitive inhibitor of N2 reduction Azotobacter vinelandii
C2H2 noncompetitive inhibitor of N2 reduction Clostridium pasteurianum
C2H2 noncompetitive inhibitor of N2 reduction Klebsiella pneumoniae
C2H2 noncompetitive inhibitor of N2 reduction Paenibacillus polymyxa
CO noncompetitive inhibitor of N2, C2H2 and N3- reduction, no inhibition of H+ reduction Azotobacter chroococcum
CO noncompetitive inhibitor of N2, C2H2 and N3- reduction, no inhibition of H+ reduction Azotobacter vinelandii
CO noncompetitive inhibitor of N2, C2H2 and N3- reduction, no inhibition of H+ reduction Clostridium pasteurianum
CO noncompetitive inhibitor of N2, C2H2 and N3- reduction, no inhibition of H+ reduction Klebsiella pneumoniae
CO noncompetitive inhibitor of N2, C2H2 and N3- reduction, no inhibition of H+ reduction Paenibacillus polymyxa
H2 competitive inhibitor of N2, no inhibition of N3-, C2H2, CN- or H+ reduction Azotobacter chroococcum
H2 competitive inhibitor of N2, no inhibition of N3-, C2H2, CN- or H+ reduction Azotobacter vinelandii
H2 competitive inhibitor of N2, no inhibition of N3-, C2H2, CN- or H+ reduction Clostridium pasteurianum
H2
-
 Klebsiella pneumoniae
H2
-
 Paenibacillus polymyxa
MgADP
-
 Azotobacter chroococcum
MgADP
-
 Azotobacter vinelandii
MgADP
-
 Clostridium pasteurianum
MgADP
-
 Klebsiella pneumoniae
MgADP
-
 Paenibacillus polymyxa

Metals/Ions

Metals/Ions Comment Organism Structure
Iron
-
 Klebsiella pneumoniae
Iron
-
 Clostridium pasteurianum
Iron
-
 Azotobacter vinelandii
Iron
-
 Paenibacillus polymyxa
Iron
-
 Azotobacter chroococcum
Mg2+ Mg2+ required for MgATP complex Klebsiella pneumoniae
Mg2+ Mg2+ required for MgATP complex Clostridium pasteurianum
Mg2+ Mg2+ required for MgATP complex Azotobacter vinelandii
Mg2+ Mg2+ required for MgATP complex Paenibacillus polymyxa
Mg2+ Mg2+ required for MgATP complex Azotobacter chroococcum
Molybdenum 1-2 gatom per mol of MoFe protein , overview Klebsiella pneumoniae
Molybdenum 1-2 gatom per mol of MoFe protein , overview Clostridium pasteurianum
Molybdenum 1-2 gatom per mol of MoFe protein , overview Azotobacter vinelandii
Molybdenum 1-2 gatom per mol of MoFe protein , overview Paenibacillus polymyxa
Molybdenum 1-2 gatom per mol of MoFe protein , overview Azotobacter chroococcum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
-
 Klebsiella pneumoniae
additional information
-
-
 Clostridium pasteurianum
additional information
-
-
 Azotobacter vinelandii
additional information
-
-
 Paenibacillus polymyxa
additional information
-
-
 Azotobacter chroococcum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O Klebsiella pneumoniae
-
 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O Clostridium pasteurianum
-
 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O Azotobacter vinelandii
-
 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O Paenibacillus polymyxa
-
 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O Azotobacter chroococcum
-
 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Azotobacter chroococcum
-
-
-
Azotobacter vinelandii
-
-
-
Clostridium pasteurianum
-
-
-
Klebsiella pneumoniae
-
-
-
Paenibacillus polymyxa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate catalytic mechanism Klebsiella pneumoniae
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate catalytic mechanism Clostridium pasteurianum
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate catalytic mechanism Azotobacter vinelandii
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate catalytic mechanism Paenibacillus polymyxa
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate catalytic mechanism Azotobacter chroococcum
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate enzyme is composed of 2 metalloproteins: component I MoFe protein and component II Fe protein Klebsiella pneumoniae
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate enzyme is composed of 2 metalloproteins: component I MoFe protein and component II Fe protein Clostridium pasteurianum
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate enzyme is composed of 2 metalloproteins: component I MoFe protein and component II Fe protein Azotobacter vinelandii
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate enzyme is composed of 2 metalloproteins: component I MoFe protein and component II Fe protein Paenibacillus polymyxa
a
4 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O = 4 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate enzyme is composed of 2 metalloproteins: component I MoFe protein and component II Fe protein Azotobacter chroococcum
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 reduced ferredoxin + 2 H+ + acetylene + 2 ATP + 2 H2O
-
 Klebsiella pneumoniae 2 oxidized ferredoxin + ethylene + 2 ADP + 2 phosphate
-
 ?
2 reduced ferredoxin + 2 H+ + acetylene + 2 ATP + 2 H2O
-
 Clostridium pasteurianum 2 oxidized ferredoxin + ethylene + 2 ADP + 2 phosphate
-
 ?
2 reduced ferredoxin + 2 H+ + acetylene + 2 ATP + 2 H2O
-
 Azotobacter vinelandii 2 oxidized ferredoxin + ethylene + 2 ADP + 2 phosphate
-
 ?
2 reduced ferredoxin + 2 H+ + acetylene + 2 ATP + 2 H2O
-
 Paenibacillus polymyxa 2 oxidized ferredoxin + ethylene + 2 ADP + 2 phosphate
-
 ?
2 reduced ferredoxin + 2 H+ + acetylene + 2 ATP + 2 H2O
-
 Azotobacter chroococcum 2 oxidized ferredoxin + ethylene + 2 ADP + 2 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O
-
 Klebsiella pneumoniae 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O
-
 Clostridium pasteurianum 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O
-
 Azotobacter vinelandii 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O
-
 Paenibacillus polymyxa 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
8 reduced ferredoxin + 8 H+ + N2 + 16 ATP + 16 H2O
-
 Azotobacter chroococcum 8 oxidized ferredoxin + H2 + 2 NH3 + 16 ADP + 16 phosphate
-
 ?
reduced ferredoxin + H+ + ATP in absence of other acceptors Klebsiella pneumoniae oxidized ferredoxin + H2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + ATP in absence of other acceptors Clostridium pasteurianum oxidized ferredoxin + H2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + ATP in absence of other acceptors Azotobacter vinelandii oxidized ferredoxin + H2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + ATP in absence of other acceptors Paenibacillus polymyxa oxidized ferredoxin + H2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + ATP in absence of other acceptors Azotobacter chroococcum oxidized ferredoxin + H2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + CN- + ATP
-
 Klebsiella pneumoniae oxidized ferredoxin + CH4 + NH3 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + CN- + ATP
-
 Clostridium pasteurianum oxidized ferredoxin + CH4 + NH3 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + CN- + ATP
-
 Azotobacter vinelandii oxidized ferredoxin + CH4 + NH3 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + CN- + ATP
-
 Paenibacillus polymyxa oxidized ferredoxin + CH4 + NH3 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + CN- + ATP
-
 Azotobacter chroococcum oxidized ferredoxin + CH4 + NH3 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N2O + ATP
-
 Klebsiella pneumoniae oxidized ferredoxin + H2O + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N2O + ATP
-
 Clostridium pasteurianum oxidized ferredoxin + H2O + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N2O + ATP
-
 Azotobacter vinelandii oxidized ferredoxin + H2O + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N2O + ATP
-
 Paenibacillus polymyxa oxidized ferredoxin + H2O + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N2O + ATP
-
 Azotobacter chroococcum oxidized ferredoxin + H2O + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N3- + ATP
-
 Klebsiella pneumoniae oxidized ferredoxin + NH3 + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N3- + ATP
-
 Clostridium pasteurianum oxidized ferredoxin + NH3 + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N3- + ATP
-
 Azotobacter vinelandii oxidized ferredoxin + NH3 + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N3- + ATP
-
 Paenibacillus polymyxa oxidized ferredoxin + NH3 + N2 + ADP + phosphate
-
 ?
reduced ferredoxin + H+ + N3- + ATP
-
 Azotobacter chroococcum oxidized ferredoxin + NH3 + N2 + ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Klebsiella pneumoniae
dimer
-
 Clostridium pasteurianum
dimer
-
 Azotobacter vinelandii
dimer
-
 Paenibacillus polymyxa
dimer
-
 Azotobacter chroococcum
More alpha-beta-monomer of the FeMo protein consists of the FeMo cofactor FeMo-co with the substrate reduction site and the [4Fe-4S] cluster Azotobacter vinelandii
tetramer
-
 Klebsiella pneumoniae
tetramer
-
 Clostridium pasteurianum
tetramer
-
 Azotobacter vinelandii
tetramer
-
 Paenibacillus polymyxa
tetramer
-
 Azotobacter chroococcum