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Literature summary for 1.18.1.2 extracted from

  • Anusevicius, Z.; Miseviciene, L.; Medina, M.; Martinez-Julvez, M.; Gomez-Moreno, C.; Cenas, N.
    FAD semiquinone stability regulates single- and two-electron reduction of quinones by Anabaena PCC7119 ferredoxin:NADP+ reductase and its Glu301Ala mutant (2005), Arch. Biochem. Biophys., 437, 144-150.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E301A 8% FAD semiquinone at the equilibrium. Mutation does not change quinone substrate specificity but confers the mixed single- and two-electron mechanism of quinone reduction, whereas wild-type uses a single-electron pathway. Change can be explained by the relative increase in the rate of second electron transfer Anabaena sp.

Organism

Organism UniProt Comment Textmining
Anabaena sp.
-
-
-
Anabaena sp. PCC7119
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,4-benzoquinone + NADP+ single electron reduction potential 0.09 V Anabaena sp. ? + NADPH + H+
-
?
1,4-benzoquinone + NADP+ single electron reduction potential 0.09 V Anabaena sp. PCC7119 ? + NADPH + H+
-
?
1,4-naphthoquinone + NADP+ single electron reduction potential -0.15 V Anabaena sp. ? + NADPH + H+
-
?
1,4-naphthoquinone + NADP+ single electron reduction potential -0.15 V Anabaena sp. PCC7119 ? + NADPH + H+
-
?
1,8-dihydroxy-9,10-anthraquinone + NADP+ single electron reduction potential -0.325 V Anabaena sp. ? + NADPH + H+
-
?
1,8-dihydroxy-9,10-anthraquinone + NADP+ single electron reduction potential -0.325 V Anabaena sp. PCC7119 ? + NADPH + H+
-
?
2,3-dichloro-1,4-naphthoquinone + NADP+ single electron reduction potential -0.035 V Anabaena sp. ? + NADPH + H+
-
?
2,3-dichloro-1,4-naphthoquinone + NADP+ single electron reduction potential -0.035 V Anabaena sp. PCC7119 ? + NADPH + H+
-
?
2,3-diglutathionyl-1,4-naphthoquinone + NADP+ single electron reduction potential -0.15 V Anabaena sp. ? + NADPH + H+
-
?
2,3-diglutathionyl-1,4-naphthoquinone + NADP+ single electron reduction potential -0.15 V Anabaena sp. PCC7119 ? + NADPH + H+
-
?
2,5-dimethyl-1,4-benzoquinone + NADP+ single electron reduction potential -0.07 V Anabaena sp. ? + NADPH + H+
-
?
2-hydroxy-1,4-naphthoquinone + NADP+ single electron reduction potential -0.41 V Anabaena sp. ? + NADPH + H+
-
?
2-methyl-1,4-benzoquinone + NADP+ single electron reduction potential 0.01 V Anabaena sp. ? + NADPH + H+
-
?
2-methyl-1,4-naphthoquinone + NADP+ single electron reduction potential -0.20 V Anabaena sp. ? + NADPH + H+
-
?
2-methyl-3-glutathionyl-1,4-naphthoquinone + NADP+ single electron reduction potential -0.16 V Anabaena sp. ? + NADPH + H+
-
?
2-methyl-3-hydroxy-1,4-naphthoquinone + NADP+ single electron reduction potential -0.46 V Anabaena sp. ? + NADPH + H+
-
?
2-methyl-5-hydroxy-1,4-naphthoquinone + NADP+ single electron reduction potential -0.16 V Anabaena sp. ? + NADPH + H+
-
?
5,8-dihydroxy-1,4-naphthoquinone + NADP+ single electron reduction potential -0.11 V Anabaena sp. ? + NADPH + H+
-
?
5-hydroxy-1,4-naphthoquinone + NADP+ single electron reduction potential -0.09 V Anabaena sp. ? + NADPH + H+
-
?
9,10-phenanthrenequinone + NADP+ single electron reduction potential -0.12 V Anabaena sp. ? + NADPH + H+
-
?
daunorubicin + NADP+ single electron reduction potential -0.34 V Anabaena sp. ? + NADPH + H+
-
?
ferricyanide + NADP+ single electron acceptor, single electron reduction potential 0.41 V Anabaena sp. ? + NADPH + H+
-
?
Fe[EDTA]- + NADP+ single electron acceptor, single electron reduction potential 0.12 V Anabaena sp. ? + NADPH + H+
-
?
methylviologen + NADP+ single electron acceptor, single electron reduction potential -0.44 V Anabaena sp. ? + NADPH + H+
-
?
tetramethyl-1,4-benzoquinone + NADP+ single electron reduction potential -0.26 V Anabaena sp. ? + NADPH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
FAD 48% FAD semiquinone at the equilibrium, pH 7.0 Anabaena sp.