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Literature summary for 1.17.99.9 extracted from

  • Merli, M.L.; Cirulli, B.A.; Menendez-Bravo, S.M.; Cricco, J.A.
    Heme A synthesis and CcO activity are essential for Trypanosoma cruzi infectivity and replication (2017), Biochem. J., 474, 2315-2332 .
    View publication on PubMed
Search for more literature for 1.17.99.9

Cloned(Commentary)

Cloned (Comment) Organism
expression of TcCOX15.HIS-GFP in yeast Trypanosoma cruzi

Protein Variants

Protein Variants Comment Organism
H129A overexpression of the non-functional TcCox15 mutants causes a negative effect over heme A synthesis, affecting the function of the CcO complex and proliferation of epimastigotes Trypanosoma cruzi
H206A overexpression of the non-functional TcCox15 mutants causes a negative effect over heme A synthesis, affecting the function of the CcO complex and proliferation of epimastigotes Trypanosoma cruzi
H307A overexpression of the non-functional TcCox15 mutants causes a negative effect over heme A synthesis, affecting the function of the CcO complex and proliferation of epimastigotes Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Trypanosoma cruzi 5739
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi V5BC58
-
-
Trypanosoma cruzi Dm28c V5BC58
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote the replicative life stages (epimastigotes and amastigotes) show higher TcCox15 levels than the infective and non-replicative stage (trypomastigotes). Two times higher level in epimastigotes than in amastigotes and five times higher level than in trypomastigotes Trypanosoma cruzi
-
epimastigote the replicative life stages (epimastigotes and amastigotes) show higher TcCox15 levels than the infective and non-replicative stage (trypomastigotes). Two times higher level in epimastigotes than in amastigotes and five times higher level than in trypomastigotes Trypanosoma cruzi
-
trypomastigote the replicative life stages (epimastigotes and amastigotes) show higher TcCox15 levels than the infective and non-replicative stage (trypomastigotes). Two times higher level in epimastigotes than in amastigotes and five times higher level than in trypomastigotes Trypanosoma cruzi
-

Synonyms

Synonyms Comment Organism
HAS
-
 Trypanosoma cruzi
TcCox15
-
 Trypanosoma cruzi

General Information

General Information Comment Organism
malfunction overexpression of a non-functional mutant causes a reduction in heme A content. This hindrance in the heme A synthesis provokes a reduction on CcO activity and, in consequence, an impairment on Trypanosoma cruzi survival, proliferation and infectivity Trypanosoma cruzi