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Literature summary for 1.17.98.4 extracted from

  • Axley, M.J.; Grahame, D.A.
    Kinetics for formate dehydrogenase of Escherichia coli formate-hydrogenlyase (1991), J. Biol. Chem., 266, 13731-13736.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
formate
-
Escherichia coli
NaNO3 competitive with respect to formate Escherichia coli
Sodium azide competitive with respect to formate Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
15
-
benzyl viologen pH 7.5, 24°C Escherichia coli
26
-
formate pH 7.5, 24°C Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formate + benzyl viologen formate oxidation is not rate-limiting in the overall coupled reaction of formate oxidation and benzyl viologen reduction Escherichia coli CO2 + reduced benzyl viologen
-
?
additional information the enzyme catalyzes carbon exchange between carbon dioxide and formate in the absence of other electron acceptors, confirming the ping-pong reaction mechanism Escherichia coli ?
-
?

Synonyms

Synonyms Comment Organism
FDHH
-
Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2833
-
formate pH 7.5, 24°C Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.08
-
Sodium azide pH 7.5, 24°C Escherichia coli
7.1
-
formate pH 7.5, 24°C Escherichia coli