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Literature summary for 1.17.98.3 extracted from

  • Wood, G.E.; Haydock, A.K.; Leigh, J.A.
    Function and regulation of the formate dehydrogenase genes of the methanogenic archaeon Methanococcus maripaludis (2003), J. Bacteriol., 185, 2548-2554.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Methanococcus maripaludis Q877E3 and Q877C5 Q877E3: alpha subunit fdhA2, Q877C5: beta subunit fdhB2, the Methanococcus maripaludis genome contains two gene clusters important for formate utilization. Phylogenetic analysis suggests that the two formate dehydrogenase gene sets arise from duplication events within the methanococcal lineage. The first gene cluster encodes homologs of formate dehydrogenase (FdhA1) and (FdhB1) subunits and a putative formate transporter (FdhC) as well as a carbonic anhydrase analog. The second gene cluster encodes only FdhA2 and FdhB2 homologs. Mutants lacking either fdhA gene exhibit a partial growth defect on formate, whereas a double mutant is completely unable to grow on formate as a sole methanogenic substrate
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Methanococcus maripaludis Q877E4 and Q877C6 Q877E4: alpha subunit fdhA1, Q877C6: beta subunit fdhB1, the Methanococcus maripaludis genome contains two gene clusters important for formate utilization. Phylogenetic analysis suggests that the two formate dehydrogenase gene sets arise from duplication events within the methanococcal lineage. The first gene cluster encodes homologs of formate dehydrogenase (FdhA1) and (FdhB1) subunits and a putative formate transporter (FdhC) as well as a carbonic anhydrase analog. The second gene cluster encodes only FdhA2 and FdhB2 homologs. Mutants lacking either fdhA gene exhibit a partial growth defect on formate, whereas a double mutant is completely unable to grow on formate as a sole methanogenic substrate
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