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Literature summary for 1.17.8.1 extracted from

  • Pan, J.J.; Solbiati, J.O.; Ramamoorthy, G.; Hillerich, B.S.; Seidel, R.D.; Cronan, J.E.; Almo, S.C.; Poulter, C.D.
    Biosynthesis of squalene from farnesyl diphosphate in bacteria: three steps catalyzed by three enzymes (2015), ACS Cent. Sci., 1, 77-82.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.8.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rhodopseudomonas palustris
expression in Escherichia coli Zymomonas mobilis

Organism

Organism UniProt Comment Textmining
Rhodopseudomonas palustris
-
-
-
Zymomonas mobilis Q56996
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hydroxysqualene + FADH2
-
 Rhodopseudomonas palustris squalene + FAD + H2O
-
 ?
hydroxysqualene + FADH2
-
 Zymomonas mobilis squalene + FAD + H2O
-
 ?

Synonyms

Synonyms Comment Organism
hpnE
-
 Rhodopseudomonas palustris
hpnE
-
 Zymomonas mobilis

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Rhodopseudomonas palustris
FAD
-
 Zymomonas mobilis

General Information

General Information Comment Organism
physiological function the reactions catalyzed by HpnC-HpnE constitute a three-step route for biosynthesis of squalene from farnesyl diphosphate. HpnD catalyzes formation of presqualene diphosphate from two molecules of farnesyl diphosphate, HpnC converts presqualene diphosphate to hydroxysqualene, and HpnE, a member of the amine oxidoreductase family, reduces hydroxysqualene to squalene Rhodopseudomonas palustris
physiological function the reactions catalyzed by HpnC-HpnE constitute a three-step route for biosynthesis of squalene from farnesyl diphosphate. HpnD catalyzes formation of presqualene diphosphate from two molecules of farnesyl diphosphate, HpnC converts presqualene diphosphate to hydroxysqualene, and HpnE, a member of the amine oxidoreductase family, reduces hydroxysqualene to squalene Zymomonas mobilis