BRENDA - Enzyme Database
show all sequences of 1.17.7.4

Overexpression and suppression of Artemisia annua 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 gene (AaHDR1) differentially regulate artemisinin and terpenoid biosynthesis

Ma, D.; Li, G.; Zhu, Y.; Xie, D.; Front. Plant Sci. 8, doi: 10.3389/fpls.2017.00077 (2017)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
chloroplast
-
Artemisia annua
9507
-
plastid
-
Artemisia annua
9536
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
Artemisia annua
-
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
Artemisia annua
-
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Artemisia annua
A0A1V0C086
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
flower
-
Artemisia annua
-
leaf
highest expression
Artemisia annua
-
root
-
Artemisia annua
-
stem
-
Artemisia annua
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
745010
Artemisia annua
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
745010
Artemisia annua
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 51405, calculated from amino acid sequence
Artemisia annua
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Artemisia annua
calculated from amino acid sequence
-
5.6
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
chloroplast
-
Artemisia annua
9507
-
plastid
-
Artemisia annua
9536
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
Artemisia annua
-
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
Artemisia annua
-
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
flower
-
Artemisia annua
-
leaf
highest expression
Artemisia annua
-
root
-
Artemisia annua
-
stem
-
Artemisia annua
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
745010
Artemisia annua
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
745010
Artemisia annua
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 51405, calculated from amino acid sequence
Artemisia annua
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Artemisia annua
calculated from amino acid sequence
-
5.6
General Information
General Information
Commentary
Organism
metabolism
enzyme overexpression leads to the increase of artemisinin production
Artemisia annua
General Information (protein specific)
General Information
Commentary
Organism
metabolism
enzyme overexpression leads to the increase of artemisinin production
Artemisia annua
Other publictions for EC 1.17.7.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
743969
Cheng
Molecular cloning and functio ...
Tripterygium wilfordii
Acta Pharm. Sin. B
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208-214
2017
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745010
Ma
Overexpression and suppressio ...
Artemisia annua
Front. Plant Sci.
8
doi: 10.3389/fpls.2017.00077
2017
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1
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1
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746563
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Cloning and bioinformatics an ...
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Zhongguo Zhong Yao Za Zhi
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Lv
Cloning and analysis of 1-hydr ...
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2015
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6
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Hsieh
The amino-terminal conserved d ...
Arabidopsis thaliana
Plant Signal. Behav.
10
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2015
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1
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2
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746146
Hsieh
The amino-terminal conserved ...
Arabidopsis thaliana
Plant Signal. Behav.
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2015
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Hsieh
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Arabidopsis thaliana
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1
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Kumar
A functional (E)-4-hydroxy-3-m ...
Stevia rebaudiana
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527
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Janthawornpong
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Burkholderia glumae
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2
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Cloning, molecular characteriz ...
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2013
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1
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1
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4
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2
1
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1
1
2
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Are free radicals involved in ...
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10
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Tritsch
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716748
Graewert
Probing the reaction mechanism ...
Escherichia coli
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2010
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1
1
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1
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5
1
1
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1
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1
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5
1
1
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1
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716772
Wang
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4522-4527
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1
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3
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1
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699809
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Molecular and functional chara ...
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2009
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