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Literature summary for 1.17.7.1 extracted from

  • Okada, K.; Hase, T.
    Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1 (2005), J. Biol. Chem., 280, 20672-20679.
    View publication on PubMed
Search for more literature for 1.17.7.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Thermosynechococcus vestitus

Metals/Ions

Metals/Ions Comment Organism Structure
[4Fe-4S]2+ cluster [4Fe-4S]2 metalloprotein Thermosynechococcus vestitus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin Thermosynechococcus vestitus essential enzyme of the non-mevalonate (2-C-methyl-D-erythritol-4-phosphate (MEP)) pathway for isoprenoid biosynthesis (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin
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 ?

Organism

Organism UniProt Comment Textmining
Thermosynechococcus vestitus Q8DK70
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Purification (Commentary)

Purification (Comment) Organism
recombinant GcpE protein is purified by an N-terminal His6 tag and reconstituted as a [4Fe-4S]2 metalloprotein Thermosynechococcus vestitus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin essential enzyme of the non-mevalonate (2-C-methyl-D-erythritol-4-phosphate (MEP)) pathway for isoprenoid biosynthesis Thermosynechococcus vestitus (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin
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 ?
2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin
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 Thermosynechococcus vestitus (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin
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 ?

Synonyms

Synonyms Comment Organism
GcpE ambiguous Thermosynechococcus vestitus

General Information

General Information Comment Organism
metabolism essential enzyme of the non-mevalonate (2-C-methyl-D-erythritol-4-phosphate (MEP)) pathway for isoprenoid biosynthesis Thermosynechococcus vestitus