Cloned (Comment) | Organism |
---|---|
expression in neural cell lines SK-N-MC and Neuro-2a, and in a human kidney cell line, HEK-293 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
I86P | mutation has only a minor effect on the activity of wild-type enzyme, but it has a dramatic effect on the activity of the VKOR-CM mutant (a mutant with mutations in the charged residues flanking transmembrane domain 1), decreasing its activity to about 10% | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | ER membrane localisation, the enzyme has a typical ER retention signal, KAKRH at the C-terminus of the protein which is indispensable to activity | Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BQB6 | vitamin K epoxide reductase complex subunit 1 | - |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme can form disulfide-linked oligomers | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
vitamin K epoxide reductase | - |
Homo sapiens |
VKOR | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | one of the key enzymes in the vitamin K cycle, which is essential for posttranslational modification of vitamin K-dependent proteins. Essential enzyme for vitamin K-dependent carboxylation | Homo sapiens |