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Literature summary for 1.17.4.4 extracted from

  • Jaenecke, F.; Friedrich-Epler, B.; Parthier, C.; Stubbs, M.T.
    Membrane composition influences the activity of in vitro refolded human vitamin K epoxide reductase (2015), Biochemistry, 54, 6454-6461 .
    View publication on PubMed
Search for more literature for 1.17.4.4

Cloned(Commentary)

Cloned (Comment) Organism
expression of mutant enzymes in Sf9 insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C132A mutation eliminates enzymatic activity in conversion of vitamin K to vitamin K hydroquinone Homo sapiens
C135A mutation eliminates enzymatic activity in conversion of vitamin K to vitamin K hydroquinone Homo sapiens
C16A about 85% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 40% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone Homo sapiens
C43A about 75% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 25% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone Homo sapiens
C43A/C51A about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. The deletion mutant enzyme retains 85% of the wild-type activity in the conversion of vitamin K 2,3-epoxide to vitamin K Homo sapiens
C51A mutant enzyme retains essentially wild-type activity in conversion of vitamin K to vitamin K hydroquinone Homo sapiens
C85A about 55% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 105% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone Homo sapiens
C96A about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. Mutant enzyme retains 40% of the wild-type activityin conversion of vitamin K to vitamin K hydroquinone Homo sapiens
DELTAC43-C51 about 50% of wild-type activity in conversion of vitamin K to vitamin K hydroquinone. The deletion mutant enzyme retains 112% of the wild-type activity in the conversion of vitamin K 2,3-epoxide to vitamin K Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
warfarin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum integral membrane enzyme of the endoplasmic reticulum Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BQB6 vitamin K epoxide reductase complex subunit 1
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-epoxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + 1,4-dithiothreitol
-
 Homo sapiens vitamin K + oxidized dithiothreitol + H2O
-
 ?
vitamin K + 1,4-dithiothreitol
-
 Homo sapiens vitamin K hydroquinone + oxidized dithiothreitol + H2O
-
 ?

Synonyms

Synonyms Comment Organism
VKOR
-
 Homo sapiens