Protein Variants | Comment | Organism |
---|---|---|
additional information | knockout of endogenous VKOR activity, i.e. VKOR and VKORC1L1 enzymes, in HEK-293 cells by transcription activator-like effector nucleases (TALENs)-mediated genome editing, overview. VKOR knockout cells regained KO reductase activity through VKORC1L1 after culturing for several generations (Figure 3A). In addition, this activity is sensitive to warfarin inhibition as the wild-type cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
warfarin | the oral anticoagulant impairs the synthesis of functional clotting factors through inhibition of VKOR and is widely used for prevention and treatment of thrombosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | Homo sapiens | - |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol | - |
Homo sapiens | 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
vitamin K epoxide reductase | - |
Homo sapiens |
VKOR | - |
Homo sapiens |
VKORC1L1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | conserved loop cysteines in VKOR are not required for active site regeneration after each cycle of oxidation | Homo sapiens |