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Literature summary for 1.17.4.4 extracted from

  • Davis, C.H.; Deerfield, D.; Wymore, T.; Stafford, D.W.; Pedersen, L.G.
    A quantum chemical study of the mechanism of action of Vitamin K epoxide reductase (VKOR) II. Transition states (2007), J. Mol. Graph. Model., 26, 401-408.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
warfarin acts by blocking vitamin K at the active site of the enzyme and thereby effectively blocking the initial step Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Reaction

Reaction Comment Organism Reaction ID
phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues quantum chemical study on mechanism and transition states. Once a key dissulfide is broken, the reaction proceeds largely downhill. The initial protonation of the epoxide oxygen is an important step, with the proton originating from a free mercapto group rather than a water molecule Homo sapiens