Inhibitors | Comment | Organism | Structure |
---|---|---|---|
warfarin | acts by blocking vitamin K at the active site of the enzyme and thereby effectively blocking the initial step | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues | quantum chemical study on mechanism and transition states. Once a key dissulfide is broken, the reaction proceeds largely downhill. The initial protonation of the epoxide oxygen is an important step, with the proton originating from a free mercapto group rather than a water molecule | Homo sapiens |