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Literature summary for 1.17.4.4 extracted from

  • Lasseur, R.; Grandemange, A.; Longin-Sauvageon, C.; Berny, P.; Benoit, E.
    Heterogeneity of the coumarin anticoagulant targeted vitamin K epoxide reduction system. Study of kinetic parameters in susceptible and resistant mice (Mus musculus domesticus) (2006), J. Biochem. Mol. Toxicol., 20, 221-229.
    View publication on PubMed
Search for more literature for 1.17.4.4

Cloned(Commentary)

Cloned (Comment) Organism
gene VKORC1, genotyping Mus musculus
gene VKORC1, genotyping Mus musculus domesticus

Protein Variants

Protein Variants Comment Organism
W59G the single nucleotide polymorphism T175G in gene VKORC1 causes 4-hydroxycoumarin derivative-resistance Mus musculus domesticus

Inhibitors

Inhibitors Comment Organism Structure
additional information mechanism of 4-hydroxycoumarin derivative-resistance, overview Mus musculus domesticus
warfarin inhibition mechanism, overview Mus musculus
warfarin slight inhibition, mechanism, overview Mus musculus domesticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Mus musculus
additional information
-
 additional information kinetics Mus musculus domesticus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-
microsome
-
 Mus musculus domesticus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol Mus musculus i.e. vitamin K 2,3-epoxide 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. vitamin K ?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol Mus musculus domesticus i.e. vitamin K 2,3-epoxide 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. vitamin K ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 warfarin-susceptible strain
-
Mus musculus domesticus
-
 warfarin-resistant strain
-

Purification (Commentary)

Purification (Comment) Organism
partially by microsome preparation Mus musculus
partially by microsome preparation Mus musculus domesticus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Mus musculus domesticus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol i.e. vitamin K 2,3-epoxide Mus musculus 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. vitamin K ?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol i.e. vitamin K 2,3-epoxide Mus musculus domesticus 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. vitamin K ?

Synonyms

Synonyms Comment Organism
vitamin K epoxide reductase
-
 Mus musculus
vitamin K epoxide reductase
-
 Mus musculus domesticus
VKOR
-
 Mus musculus
VKOR
-
 Mus musculus domesticus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus
30
-
 assay at Mus musculus domesticus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Mus musculus domesticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Mus musculus
additional information
-
 additional information inhibition kinetics Mus musculus domesticus
0.006
-
 warfarin pH 7.4, 30°C Mus musculus