Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
gene VKORC1, located on chromosome 1, DNA and amino acid sequenc determination and analysis, expression of wild-type and warfarin-resistant mutant enzymes in HEK-293 cells, expression of the latter alomost completely abolishes the enzyme activity | Rattus norvegicus |
gene VKORC1, located on chromosome 16, DNA and amino acid sequenc determination and analysis, genetic structure, expression in Spodoptera frugiperda Sf9 cells and in Pichia pastoris | Homo sapiens |
gene VKORC1, located on chromosome 7, DNA and amino acid sequenc determination and analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | allelic mutations in the orthologous gene can cause warfarin resistance | Rattus norvegicus |
additional information | allelic mutations in the orthologous gene of VKORC1 can cause warfarin resistance | Mus musculus |
additional information | deficient enzyme mutants cause VKCFD2 disease phenotype | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phenprocoumon | 4-hydroxycoumarin-derived anticoagulation drug, blocks the recycling of vitamin K epoxid inhibiting the two dithiol-dependent steps performed by the enzyme | Homo sapiens | |
phenprocoumon | - |
Mus musculus | |
phenprocoumon | - |
Rattus norvegicus | |
warfarin | 4-hydroxycoumarin-derived anticoagulation drug, blocks the recycling of vitamin K epoxid inhibiting the two dithiol-dependent steps performed by the enzyme | Homo sapiens | |
warfarin | - |
Mus musculus | |
warfarin | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | membrane topology, overview | Mus musculus | 5789 | - |
endoplasmic reticulum membrane | membrane topology, overview | Rattus norvegicus | 5789 | - |
endoplasmic reticulum membrane | the enzyme possesses 3 or 4 transmembrane alpha-helices and a large cytoplasmic loop, membrane topology, overview | Homo sapiens | 5789 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
18000 | - |
x * 18000 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Mus musculus | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Homo sapiens | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | Rattus norvegicus | i.e. vitamin K 2,3-epoxide | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
additional information | Homo sapiens | the VKCFD2 disease, a vitamin K-dependent clotting factor deficiency, is caused by enzyme mutations, VKORC1 is the key component of the vitamin K reductase activity targeted by coumarin-derived drugs in prophylaxis and therapy of thrombosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene VKORC1 | - |
Mus musculus | - |
gene VKORC1 | - |
Rattus norvegicus | - |
gene VKORC1 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues | protein structure and catalytic mechanism, the enzyme activity is rate-limiting for the following gamma-carboxylation step | Mus musculus | |
phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues | protein structure and catalytic mechanism, the enzyme activity is rate-limiting for the following gamma-carboxylation step | Homo sapiens | |
phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues | protein structure and catalytic mechanism, the enzyme activity is rate-limiting for the following gamma-carboxylation step | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | fetal and adult | Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | - |
Rattus norvegicus | - |
kidney | fetal | Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
liver | fetal and adult | Homo sapiens | - |
lung | fetal | Homo sapiens | - |
pancreas | adult | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Mus musculus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Homo sapiens | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide | Rattus norvegicus | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol | i.e. vitamin K 2,3-epoxide, two dithiol-dependent steps | Homo sapiens | 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol | i.e. vitamin K | ? | |
additional information | the VKCFD2 disease, a vitamin K-dependent clotting factor deficiency, is caused by enzyme mutations, VKORC1 is the key component of the vitamin K reductase activity targeted by coumarin-derived drugs in prophylaxis and therapy of thrombosis | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 18000 | Homo sapiens |
More | the enzyme possesses a dicoumarol binding hydrophobic sequence motif TYA, VKOR complex structure, overview | Homo sapiens |
More | VKOR complex structure, overview | Mus musculus |
More | VKOR complex structure, overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
vitamin K epoxide reductase | - |
Mus musculus |
vitamin K epoxide reductase | - |
Homo sapiens |
vitamin K epoxide reductase | - |
Rattus norvegicus |
vitamin K epoxide reductase complex subunit 1 | - |
Mus musculus |
vitamin K epoxide reductase complex subunit 1 | - |
Homo sapiens |
vitamin K epoxide reductase complex subunit 1 | - |
Rattus norvegicus |
VKOR | - |
Mus musculus |
VKOR | - |
Homo sapiens |
VKOR | - |
Rattus norvegicus |
VKORC1 | - |
Mus musculus |
VKORC1 | - |
Homo sapiens |
VKORC1 | - |
Rattus norvegicus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | sequence calculation | - |
10.7 |