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Literature summary for 1.17.4.4 extracted from
- Vitamin K epoxide reductase: homology, active site and catalytic mechanism (2004), Trends Biochem. Sci., 29, 289-292.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R98W | two patients suffering from combined deficiency of vitamin K-dependent clotting factors type 2 possess a R98W substitution at the presumed cytoplasmic end of TM alpha-helix 2 of vitamin-K-epoxide reductase. Because the residue is far-removed from the proposed active site its mutation is, therefore assumed to disrupt VKORC1 structure or VKOR complex assembly rather than catalysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| vitamin K1 2,3-epoxide + dithiothreitol | Homo sapiens | two patients suffering from combined deficiency of vitamin K-dependent clotting factors type 2 possess a R98W substitution at the presumed cytoplasmic end of TM alpha-helix 2. Because the residue is far-removed from the proposed active site its mutation is, therefore assumed to disrupt VKORC1 structure or VKOR complex assembly rather than catalysis | vitamin K1 + oxidized dithiothreitol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| vitamin K1 2,3-epoxide + dithiothreitol | - |
Homo sapiens | vitamin K1 + oxidized dithiothreitol | - |
? | |
| vitamin K1 2,3-epoxide + dithiothreitol | two patients suffering from combined deficiency of vitamin K-dependent clotting factors type 2 possess a R98W substitution at the presumed cytoplasmic end of TM alpha-helix 2. Because the residue is far-removed from the proposed active site its mutation is, therefore assumed to disrupt VKORC1 structure or VKOR complex assembly rather than catalysis | Homo sapiens | vitamin K1 + oxidized dithiothreitol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| VKOR complex | - |
Homo sapiens |
| VKORC1 | catalytic subunit of the VKOR complex | Homo sapiens |
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