Application | Comment | Organism |
---|---|---|
medicine | the enzyme is the therapeutic target site for warfarin, an anticoagulant that is prescribed widely for the treatment and prevention of thrombosis. Point mutations in VKORC1 may be an important, though rare, cause of warfarin resistance in anticoagulation clinic populations | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
V66M | mutation is responsible for warfarin resistance phenotype | Homo sapiens |
V66M | naturally occuring VKORC1 mutant showing warfarin-resistance, patients with this mutation need a very high dosage of anticoagulants in therapy, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | pharmacodynamics of resistance to warfarin, overview | Homo sapiens | |
warfarin | the enzyme is the therapeutic target site for warfarin, an anticoagulant that is prescribed widely for the treatment and prevention of thrombosis. Point mutations in VKORC1 may be an important, though rare, cause of warfarin resistance in anticoagulation clinic populations. V66M mutation is responsible for warfarin resistance phenotype | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is involved in coagulation factor activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
mutant V66M | - |
Homo sapiens | Q9BQB6 | wild-type enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in coagulation factor activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
vitamin K epoxide reductase complex subunit 1 | - |
Homo sapiens |
VKORC1 | - |
Homo sapiens |