Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Rattus norvegicus | |
dithiothreitol | - |
Bos taurus | |
GSH | activation, 6% as effective as DTT | Rattus norvegicus | |
GSH | activation, 6% as effective as DTT | Bos taurus | |
lipoic acid | activation, less effective than DTT | Rattus norvegicus | |
lipoic acid | activation, less effective than DTT | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
warfarin | - |
Bos taurus | |
warfarin | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | integral membrane protein | Rattus norvegicus | - |
- |
microsome | integral membrane protein | Bos taurus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
vitamin K 2,3-epoxide + dithiothreitol | Bos taurus | - |
vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | Rattus norvegicus | thioredoxin is the possible physiological electron acceptor | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | Rattus norvegicus Wistar | thioredoxin is the possible physiological electron acceptor | vitamin K + oxidized dithiothreitol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Rattus norvegicus | - |
Wistar strain | - |
Rattus norvegicus Wistar | - |
Wistar strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | - |
Bos taurus | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | thioredoxin is the possible physiological electron acceptor | Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | - |
Rattus norvegicus Wistar | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | thioredoxin is the possible physiological electron acceptor | Rattus norvegicus Wistar | vitamin K + oxidized dithiothreitol | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
reduced thioredoxin | likely physiological cofactor, more potent than dithiothreitol | Rattus norvegicus | |
reduced thioredoxin | likely physiological cofactor, more potent than dithiothreitol | Bos taurus |