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Literature summary for 1.17.4.4 extracted from

  • Ryall, R.P.; Nandi, D.L.; Silverman, R.B.
    Substituted vitamin K epoxide analogues. New competitive inhibitors and substrates of vitamin K1 epoxide reductase (1990), J. Med. Chem., 33, 1790-1797.
    View publication on PubMed
Search for more literature for 1.17.4.4

Inhibitors

Inhibitors Comment Organism Structure
Vitamin K 2,3-epoxide analogs hydroxymethyl-, chloromethyl-, fluoromethyl-, difluoromethyl-, formyl-analogs and analogs with modified phytyl chain, competitive inhibition Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome integral membrane protein Rattus norvegicus
-
-
microsome integral membrane protein Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxymethyl-vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus 2-hydroxymethyl-vitamin K + oxidized dithiothreitol
-
 ?
2-hydroxymethyl-vitamin K 2,3-epoxide + dithiothreitol
-
 Bos taurus 2-hydroxymethyl-vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol
-
 Bos taurus vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide analogs + dithiothreitol such as hydroxymethyl-, chloromethyl-, fluoromethyl-, difluoromethyl-, and formyl-analogs Rattus norvegicus ?
-
 ?
vitamin K 2,3-epoxide analogs + dithiothreitol such as hydroxymethyl-, chloromethyl-, fluoromethyl-, difluoromethyl-, and formyl-analogs Bos taurus ?
-
 ?