Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1,2-Ethanedithiol | activation | Rattus norvegicus | |
1,4-Butanedithiol | activation | Rattus norvegicus | |
dithioerythritol | equally effective as DTT | Rattus norvegicus | |
dithiothreitol | DL-DTT and L-DTT equally effective | Rattus norvegicus | |
lipoic acid | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not inhibited by iodoacetic acid | Rattus norvegicus | |
N-ethylmaleimide | inhibition increased if the enzyme is prereduced by DTT, 1,4-butanedithiol or 1,2-ethanediol | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | integral membrane protein | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
vitamin K 2,3-epoxide + dithiothreitol | Rattus norvegicus | reaction in metabolic pathway of vitamin K | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | Rattus norvegicus Wistar | reaction in metabolic pathway of vitamin K | vitamin K + oxidized dithiothreitol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar strain | - |
Rattus norvegicus Wistar | - |
Wistar strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
vitamin K 2,3-epoxide + dithiothreitol | 2-mercaptoethanol, reduced glutathione, cysteine and 1,6-hexanedithiol are inactive as acceptors | Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | reaction in metabolic pathway of vitamin K | Rattus norvegicus | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | 2-mercaptoethanol, reduced glutathione, cysteine and 1,6-hexanedithiol are inactive as acceptors | Rattus norvegicus Wistar | vitamin K + oxidized dithiothreitol | - |
? | |
vitamin K 2,3-epoxide + dithiothreitol | reaction in metabolic pathway of vitamin K | Rattus norvegicus Wistar | vitamin K + oxidized dithiothreitol | - |
? |