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Literature summary for 1.17.4.4 extracted from

  • Friedman, P.A.; Griep, A.E.
    In vitro inhibition of vitamin K dependent carboxylation by tetrachloropyridinol and the imidazopyridines (1980), Biochemistry, 19, 3381-3386.
    View publication on PubMed
Search for more literature for 1.17.4.4

Inhibitors

Inhibitors Comment Organism Structure
1-hydroxyimidazopyridine 4.0 mM, 9% inhibition, warfarin-resistant rats Rattus norvegicus
2,3,5,6-Tetrachloro-4-pyridinol 2.0 mM, 45% inhibition, warfarin-resistant rats Rattus norvegicus
coumarin anticoagulants
-
 Rattus norvegicus
Imidazopyridines
-
 Rattus norvegicus
warfarin 0.01 mM, 18% inhibition, 0.1 mM, 64% inhibition, warfarin-resistant rats Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-
microsome integral membrane protein Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol Rattus norvegicus
-
 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
 ?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol Rattus norvegicus Holtzman
-
 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus
-
 Holtzman strain
-
Rattus norvegicus Holtzman
-
 Holtzman strain
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Storage Stability

Storage Stability Organism
4°C, acetone powder, stable Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
 Rattus norvegicus 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
 ?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol i.e. vitamin K 2,3-epoxide Rattus norvegicus 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. 3-hydroxy-2,3-dihydro-vitamin K ?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol
-
 Rattus norvegicus Holtzman 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol
-
 ?
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol i.e. vitamin K 2,3-epoxide Rattus norvegicus Holtzman 2-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol i.e. 3-hydroxy-2,3-dihydro-vitamin K ?
vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus vitamin K + oxidized dithiothreitol
-
 ?
vitamin K 2,3-epoxide + dithiothreitol
-
 Rattus norvegicus Holtzman vitamin K + oxidized dithiothreitol
-
 ?