Protein Variants | Comment | Organism |
---|---|---|
C119S | site-directed mutagenesis | Lactobacillus leichmannii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',2'-difluoro-2'-deoxycytidine 5'-triphosphate | F2CTP, a clinically used anti-cancer drug, synthesis, overview. Causes rapid enzyme inactivation through covalent modification, mechanism of inactivation, analysis by mass spectrometry and radio- or deuterium-labeled compounds, overview. C119 is involved in the reaction | Lactobacillus leichmannii | |
2'-chloro-2'-deoxy-UTP | - |
Lactobacillus leichmannii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
76000 | - |
- |
Lactobacillus leichmannii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Lactobacillus leichmannii | RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Lactobacillus leichmannii | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + adenosylcobalamin | - |
Lactobacillus leichmannii | ? | - |
? | |
additional information | RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor | Lactobacillus leichmannii | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 76000 | Lactobacillus leichmannii |
Synonyms | Comment | Organism |
---|---|---|
class II RNR | - |
Lactobacillus leichmannii |
nucleoside triphosphate reductase | - |
Lactobacillus leichmannii |
ribonucleotide reductase | - |
Lactobacillus leichmannii |
RNR | - |
Lactobacillus leichmannii |
RTPR | - |
Lactobacillus leichmannii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Lactobacillus leichmannii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Lactobacillus leichmannii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
adenosylcobalamin | - |
Lactobacillus leichmannii |