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Literature summary for 1.17.4.2 extracted from

  • Lohman, G.J.; Stubbe, J.
    Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: covalent modification (2010), Biochemistry, 49, 1404-1417.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C119S site-directed mutagenesis Lactobacillus leichmannii

Inhibitors

Inhibitors Comment Organism Structure
2',2'-difluoro-2'-deoxycytidine 5'-triphosphate F2CTP, a clinically used anti-cancer drug, synthesis, overview. Causes rapid enzyme inactivation through covalent modification, mechanism of inactivation, analysis by mass spectrometry and radio- or deuterium-labeled compounds, overview. C119 is involved in the reaction Lactobacillus leichmannii
2'-chloro-2'-deoxy-UTP
-
Lactobacillus leichmannii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
76000
-
-
Lactobacillus leichmannii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Lactobacillus leichmannii RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor ?
-
?

Organism

Organism UniProt Comment Textmining
Lactobacillus leichmannii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + adenosylcobalamin
-
Lactobacillus leichmannii ?
-
?
additional information RTPR catalyzes the conversion of nucleoside triphosphates to deoxynucleotides using adenosylcobalamin as a cofactor Lactobacillus leichmannii ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 76000 Lactobacillus leichmannii

Synonyms

Synonyms Comment Organism
class II RNR
-
Lactobacillus leichmannii
nucleoside triphosphate reductase
-
Lactobacillus leichmannii
ribonucleotide reductase
-
Lactobacillus leichmannii
RNR
-
Lactobacillus leichmannii
RTPR
-
Lactobacillus leichmannii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Lactobacillus leichmannii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Lactobacillus leichmannii

Cofactor

Cofactor Comment Organism Structure
adenosylcobalamin
-
Lactobacillus leichmannii