Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.4.2 extracted from

  • Gleason, F.K.; Frick, T.D.
    Adenosylcobalamin-dependent ribonucleotide reductase from the blue-green alga, Anabaena sp. Purification and partial characterization (1980), J. Biol. Chem., 255, 7728-7733.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dATP specific activator for CTP reduction Anabaena sp.
dATP specific activator for CTP reduction Lactobacillus leichmannii
dGTP specific activator for ATP reduction Anabaena sp.
dGTP specific activator for ATP reduction Lactobacillus leichmannii
dTTP
-
Lactobacillus leichmannii
dTTP specific activator for GTP reduction Anabaena sp.

Inhibitors

Inhibitors Comment Organism Structure
K+
-
Anabaena sp.
Na+
-
Anabaena sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
CTP presence of 0.05 mM dATP Anabaena sp.

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ absolutely dependent on Anabaena sp.
Mg2+ stabilized by Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
1 * 50000, SDS-PAGE Anabaena sp.
72000
-
gel filtration Anabaena sp.
76000
-
-
Lactobacillus leichmannii
240000
-
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ribonucleoside triphosphate + reduced thioredoxin + H2O Escherichia coli
-
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O Anabaena sp.
-
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O Lactobacillus leichmannii
-
2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r

Organism

Organism UniProt Comment Textmining
Anabaena sp.
-
-
-
Anabaena sp. 7119
-
-
-
Escherichia coli
-
-
-
Lactobacillus leichmannii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Anabaena sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
77.25
-
-
Anabaena sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + reduced thioredoxin
-
Anabaena sp. dATP + oxidized thioredoxin + H2O
-
?
ATP + reduced thioredoxin
-
Lactobacillus leichmannii dATP + oxidized thioredoxin + H2O
-
?
CTP + reduced thioredoxin
-
Anabaena sp. dCTP + oxidized thioredoxin + H2O
-
?
CTP + reduced thioredoxin
-
Lactobacillus leichmannii dCTP + oxidized thioredoxin + H2O
-
?
GTP + reduced thioredoxin
-
Anabaena sp. dGTP + oxidized thioredoxin + H2O
-
?
GTP + reduced thioredoxin
-
Lactobacillus leichmannii dGTP + oxidized thioredoxin + H2O
-
?
ribonucleoside triphosphate + 2-hydroxyethyl disulfide
-
Anabaena sp. 2'-deoxyribonucleoside triphosphate + 2-mercaptoethanol + H2O
-
?
ribonucleoside triphosphate + dihydrolipoate
-
Anabaena sp. 2'-deoxyribonucleoside triphosphate + lipoate + H2O
-
?
ribonucleoside triphosphate + dihydrolipoate
-
Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + lipoate + H2O
-
?
ribonucleoside triphosphate + dihydrolipoate
-
Anabaena sp. 7119 2'-deoxyribonucleoside triphosphate + lipoate + H2O
-
?
ribonucleoside triphosphate + dithioerythritol
-
Anabaena sp. 2'-deoxyribonucleoside triphosphate + ? + H2O
-
?
ribonucleoside triphosphate + dithioerythritol
-
Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + ? + H2O
-
?
ribonucleoside triphosphate + dithioerythritol
-
Anabaena sp. 7119 2'-deoxyribonucleoside triphosphate + ? + H2O
-
?
ribonucleoside triphosphate + dithiothreitol
-
Anabaena sp. 2'-deoxyribonucleoside triphosphate + ? + H2O
-
?
ribonucleoside triphosphate + dithiothreitol
-
Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + ? + H2O
-
?
ribonucleoside triphosphate + dithiothreitol
-
Anabaena sp. 7119 2'-deoxyribonucleoside triphosphate + ? + H2O
-
?
ribonucleoside triphosphate + GSSG
-
Anabaena sp. 2'-deoxyribonucleoside triphosphate + GSH + H2O
-
?
ribonucleoside triphosphate + GSSG
-
Anabaena sp. 7119 2'-deoxyribonucleoside triphosphate + GSH + H2O
-
?
ribonucleoside triphosphate + NADP+
-
Anabaena sp. 2'-deoxyribonucleoside triphosphate + NADPH + H2O
-
?
ribonucleoside triphosphate + reduced thioredoxin
-
Escherichia coli 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
ribonucleoside triphosphate + reduced thioredoxin
-
Anabaena sp. 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
ribonucleoside triphosphate + reduced thioredoxin
-
Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
ribonucleoside triphosphate + reduced thioredoxin
-
Anabaena sp. 7119 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
-
Escherichia coli 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
-
Anabaena sp. 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
ribonucleoside triphosphate + reduced thioredoxin + H2O
-
Lactobacillus leichmannii 2'-deoxyribonucleoside triphosphate + oxidized thioredoxin + H2O
-
r
UTP + reduced thioredoxin
-
Anabaena sp. dUTP + oxidized thioredoxin + H2O
-
?
UTP + reduced thioredoxin
-
Lactobacillus leichmannii dUTP + oxidized thioredoxin + H2O
-
?

Subunits

Subunits Comment Organism
dimer
-
Escherichia coli
monomer
-
Lactobacillus leichmannii
monomer 1 * 50000, SDS-PAGE Anabaena sp.

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Anabaena sp.

Cofactor

Cofactor Comment Organism Structure
coenzyme B12 adenosylcobalamin Lactobacillus leichmannii