Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
serovar Typhimurium, inside RAW264.7 macrophages or HeLa cells | - |
Synonyms | Comment | Organism |
---|---|---|
class Ib RNR | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
General Information | Comment | Organism |
---|---|---|
additional information | transcriptional regulation of RNR classes as well as their differential function during infection of macrophage and epithelial cells, overview | Salmonella enterica subsp. enterica serovar Typhimurium |
physiological function | role of RNRs during infection of macrophages and epithelial cells, overview. Class Ia to be mainly responsible for deoxyribonucleotide production during invasion and proliferation inside macrophages and epithelial cells, while class Ib RNR is not. Class Ib RNR may contribute to deoxyribonucleotide synthesis by means of both an NrdR and a Fur-dependent derepression of nrdHIEF due to hydrogen peroxide production and DNA damage associated with the oxidative burst, thus helping to overcome the host defenses | Salmonella enterica subsp. enterica serovar Typhimurium |