Literature summary for 1.17.4.1 extracted from

Yun, D.; Krebs, C.; Gupta, G.P.; Iwig, D.F.; Huynh, B.H.; Bollinger, J.M., Jr.
Facile electron transfer during formation of cluster x and kinetic competence of x for tyrosyl radical production in protein R2 of ribonucleotide reductase from mouse (2002), Biochemistry, 41, 981-990.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of wild-type and Y177F mutant subunit R2 in Escherichia coli	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
Y177F	tyrosyl residue involved in radical formation	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	the essential metallo-cofactor is a micro-oxo-micro-carboxylato-diiron cluster adjacent to a stable tyrosyl radical	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin	kinetics and mechanism of formation of the tyrosyl radical and micro-oxo-diiron cluster in the R2 subunit	Mus musculus	a

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Release 2023.1 (January 2023)