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Literature summary for 1.17.4.1 extracted from

  • Cory, J.G.; Cory, A.H.; Downes, D.L.
    Differential substrate properties of mammalian ribonucleotide reductase (1995), Purine and pyrimidine metabolism in man VIII ed. (Sahota A. and Taylor M. ed.), , 631-635.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
monoclonal antibody raised against yeast tubulin CDP reductase activity is inhibited to a greater extent than ADP, UDP or GDP reductase activity, antibody recognizes a specific sequence in the C-terminal region on the R2 subunit Mus musculus
NSFTLDADF inhibition of CDP reductase activity, peptide corresponds to the C-terminal region of the R2 subunit and competes with binding of R2 to the R1 subunit Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
Ehrlich ascites tumor cells
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ribonucleoside diphosphate + reduced thioredoxin
-
Mus musculus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
ir

Subunits

Subunits Comment Organism
More large subunit R1 contains binding sites for substrates and allosteric effectors, smaller subunit R2 contains non-heme iron and a tyrosyl free-radical Mus musculus