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Literature summary for 1.17.4.1 extracted from
- Functional regulation of mammalian ribonucleotide reductase (1972), Adv. Enzyme Regul., 10, 19-38.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | enzyme from Novikoff hepatoma tumor cells is associated with a smooth membrane component of the cytoplasm | Rattus norvegicus | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ribonucleoside diphosphate + reduced thioredoxin | Rattus norvegicus | critical and rate-controlling step in pathway leading to DNA synthesis and cell replication | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
? |  |
| ribonucleoside diphosphate + reduced thioredoxin | Rattus norvegicus | thioredoxin is the physiological reductant | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Morris hepatoma cells | - |
| Rattus norvegicus | - |
Novikoff hepatoma cells | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
strong increase of specific activity during growth of Novikoff hepatoma cells | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ribonucleoside diphosphate + reduced thioredoxin | - |
Rattus norvegicus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
ir | |
| ribonucleoside diphosphate + reduced thioredoxin | critical and rate-controlling step in pathway leading to DNA synthesis and cell replication | Rattus norvegicus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
? | |
| ribonucleoside diphosphate + reduced thioredoxin | thioredoxin is the physiological reductant | Rattus norvegicus | 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O | - |
? | |
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Release 2023.1 (January 2023)
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