Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.17.4.1 extracted from

  • Averett, D.R.; Furman, P.A.; Spector, T.
    Ribonucleotide reductase of herpes simplex virus type 2 resembles that of herpes simplex virus type 1 (1984), J. Virol., 52, 981-983.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
ADP competitive inhibition of CDP reduction Herpes simplex virus
ATP free ATP, 0.32 mM, 50% inhibition Herpes simplex virus
CDP competitive inhibition of ADP reduction Herpes simplex virus
Mg2+ uncomplexed Mg2+, 3.7 mM, 50% inhibition Herpes simplex virus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00049
-
CDP
-
Herpes simplex virus
0.0078
-
ADP
-
Herpes simplex virus

Organism

Organism UniProt Comment Textmining
Herpes simplex virus
-
type 2, HSV-2
-

Purification (Commentary)

Purification (Comment) Organism
HSV type 2 Herpes simplex virus

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.3
-
Herpes simplex virus type 2 enzyme, CDP reduction Herpes simplex virus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + thioredoxin
-
Herpes simplex virus 2'-dADP + thioredoxin disulfide + H2O
-
r
CDP + thioredoxin
-
Herpes simplex virus 2'-dCDP + thioredoxin disulfide + H2O
-
r
ribonucleoside diphosphate + reduced thioredoxin
-
Herpes simplex virus 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
ir

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00042
-
CDP competitive inhibition of ADP reduction Herpes simplex virus
0.011
-
ADP competitive inhibition of CDP reduction Herpes simplex virus