Literature summary for 1.17.4.1 extracted from

Kjoller Larsen, I.; Sj�berg, B.M.; Thelander, L.
Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues (1982), Eur. J. Biochem., 125, 75-81.

Inhibitors

Inhibitors	Comment	Organism
1-methyl-1-hydroxyurea	10 mM, 55% inhibition	Escherichia coli
2,3,4-trihydroxybenzohydroxamic acid	0.009 mM, 50% inhibition, reversible	Bos taurus
2,3,4-trihydroxybenzohydroxamic acid	0.012 mM, 50% inhibition, hydroxyurea-resistant cells	Mus musculus
3,4-dihydroxybenzohydroxamic acid	0.033 mM, 50% inhibition, reversible	Bos taurus
3,4-dihydroxybenzohydroxamic acid	2.5 mM, 50% inhibition	Escherichia coli
3,4-dihydroxybenzohydroxamic acid	0.3 mM, 50% inhibition	Tequatrovirus T4
3-methyl-1-hydroxyurea	10 mM, 57% inhibition	Escherichia coli
formohydroxamic acid	10 mM, 43% inhibition	Escherichia coli
hydroxylamine	10 mM, complete inhibition	Escherichia coli
Hydroxyurea	-	Bos taurus
Hydroxyurea	10 mM, complete inhibition, 0.3 mM, 50% inhibition	Escherichia coli
Hydroxyurea	-	Mus musculus
Hydroxyurea	0.025 mM, 50% inhibition	Tequatrovirus T4
N,2,3,4-tetrahydroxybenzamide	0.012 mM, 50% inhibition, reversible	Bos taurus
N-hydroxyguanidine	10 mM, 89% inhibition	Escherichia coli
N-hydroxyurethane	10 mM, 66% inhibition	Escherichia coli
N-Methylhydroxylamine	10 mM, 94% inhibition	Escherichia coli
Polyhydroxybenzohydroxamic acid	-	Escherichia coli
Polyhydroxybenzohydroxamic acid	-	Mus musculus
Polyhydroxybenzohydroxamic acid	-	Tequatrovirus T4

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Escherichia coli	-	-	-
Mus musculus	-	-	-
Tequatrovirus T4	-	-	-

Source Tissue	Comment	Organism	Textmining
fibroblast	-	Mus musculus	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
ribonucleoside diphosphate + reduced thioredoxin	-	Mus musculus	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir
ribonucleoside diphosphate + reduced thioredoxin	-	Escherichia coli	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir
ribonucleoside diphosphate + reduced thioredoxin	-	Bos taurus	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir
ribonucleoside diphosphate + reduced thioredoxin	-	Tequatrovirus T4	2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O	-	ir