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Literature summary for 1.17.3.2 extracted from

  • Lopez-Cruz, R.I.; Perez-Milicua, M.B.; Crocker, D.E.; Gaxiola-Robles, R.; Bernal-Vertiz, J.A.; de la Rosa, A.; Vazquez-Medina, J.P.; Zenteno-Savin, T.
    Purine nucleoside phosphorylase and xanthine oxidase activities in erythrocytes and plasma from marine, semiaquatic and terrestrial mammals (2014), Comp. Biochem. Physiol. A, 171, 31-35 .
    View publication on PubMed
Search for more literature for 1.17.3.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + H2O + O2 Homo sapiens
-
 urate + H2O2
-
 ?
xanthine + H2O + O2 Tursiops truncatus
-
 urate + H2O2
-
 ?
xanthine + H2O + O2 Lontra longicaudis annectens
-
 urate + H2O2
-
 ?
xanthine + H2O + O2 Mirounga angustirostris
-
 urate + H2O2
-
 ?
xanthine + H2O + O2 Sus scrofa
-
 urate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P47989
-
-
Lontra longicaudis annectens
-
-
-
Mirounga angustirostris H9A5F8
-
-
Sus scrofa F1S3Y7
-
-
Tursiops truncatus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Tursiops truncatus
-
blood plasma
-
 Lontra longicaudis annectens
-
blood plasma
-
 Sus scrofa
-
blood plasma low activity Homo sapiens
-
blood plasma enzyme activity in plasma of northern elephant seals during prolonged fasting and rest and voluntary associated apneas Mirounga angustirostris
-
erythrocyte
-
 Homo sapiens
-
erythrocyte
-
 Tursiops truncatus
-
erythrocyte
-
 Lontra longicaudis annectens
-
erythrocyte
-
 Mirounga angustirostris
-
erythrocyte
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 mean activity in plasma is 0.34 mU/ml Tursiops truncatus
additional information
-
 mean activity in plasma is 0.36 mU/ml Sus scrofa
additional information
-
 mean activity in plasma is 0.52 mU/ml Lontra longicaudis annectens
additional information
-
 mean activity in plasma is 0.591 mU/ml Homo sapiens
additional information
-
 mean activity in plasma is 2.04 mU/ml Mirounga angustirostris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + H2O + O2
-
 Homo sapiens urate + H2O2
-
 ?
xanthine + H2O + O2
-
 Tursiops truncatus urate + H2O2
-
 ?
xanthine + H2O + O2
-
 Lontra longicaudis annectens urate + H2O2
-
 ?
xanthine + H2O + O2
-
 Mirounga angustirostris urate + H2O2
-
 ?
xanthine + H2O + O2
-
 Sus scrofa urate + H2O2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens
37
-
 assay at Tursiops truncatus
37
-
 assay at Lontra longicaudis annectens
37
-
 assay at Mirounga angustirostris
37
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens
7.5
-
 assay at Tursiops truncatus
7.5
-
 assay at Lontra longicaudis annectens
7.5
-
 assay at Mirounga angustirostris
7.5
-
 assay at Sus scrofa

General Information

General Information Comment Organism
evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Homo sapiens
evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Tursiops truncatus
evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Lontra longicaudis annectens
evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Mirounga angustirostris
evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Sus scrofa
metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Tursiops truncatus
metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Lontra longicaudis annectens
metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Mirounga angustirostris
metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Sus scrofa
metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purinesalvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Homo sapiens