Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | XOR activity is specifically increased by inflammatory mononuclear phagocyte differentiation | Rattus norvegicus | |
Th-1 cytokine | increases XOR activity in inflammatory mononuclear phagocytes in vivo | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
ectopic overexpression of XOR cDNA and uric acid supplementation reducing SUMO-PPARgamma in inflammatory mononuclear phagocytes | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid | - |
Rattus norvegicus | |
allopurinol | - |
Rattus norvegicus | |
oxypurinol | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male | - |
Rattus norvegicus Sprague-Dawley | - |
male | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | alveolar macrophages purified from the lung by lavage, and interstitial macrophages. Inflammatory cells express high levels of XOR activity, while in resident alveolar macrophage the enzyme content is extremely low prior to cytokine insufflation | Rattus norvegicus | - |
NR-8383 cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
xanthine oxidoreductase | - |
Rattus norvegicus |
XOR | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | effects of enzyme inhibition in inflammatory macrophages, overview | Rattus norvegicus |
additional information | xanthine oxidoreductase is implicated in many inflammatory diseases. Inhibition of XOR within the inflammatory mononuclear phagocytes, i.e. MNP, prevents neutrophil recruitment during adoptive transfer demonstrating the role of XOR in MNP-mediated neutrophil recruitment, role of XOR in the inflammatory state of MNP, overview. XOR activity is specifically increased by inflammatory mononuclear phagocyte differentiation. Inhibition of XOR reduces levels of CINC-1 secreted by inflammatory mononuclear phagocytes, and increases levels of SUMO-PPARgamma in the cell lines | Rattus norvegicus |