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Literature summary for 1.17.3.2 extracted from
- Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice (2011), Food Chem. Toxicol., 49, 1943-1947.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| apigenin | increases liver xanthine oxidase activities significantly, but has no effect on serum xanthine oxidase activities | Mus musculus |  |
| astilbin | significantly increases serum xanthine oxidase activities, and decreases liver xanthine oxidase activities significantly | Mus musculus | |
| quercetin | significantly increases serum xanthine oxidase activities, and decreases liver xanthine oxidase activities significantly | Mus musculus | |
| rutin | significantly increases serum xanthine oxidase activities | Mus musculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| allopurinol | decreasesserum xanthine oxidase activity but increases liver xanthine oxidase activity significantly | Mus musculus | |
| additional information | inhibition of xanthine oxidase by thiosemicarbazones, hydrazones and dithiocarbazates derived from hydroxy-substituted benzaldehydes, overview | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Mus musculus | - |
- |
| intracellular | - |
Mus musculus | 5622 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| xanthine + H2O + O2 | Mus musculus | - |
urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | Mus musculus BALB/c | - |
urate + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
male mice | - |
| Mus musculus BALB/c | - |
male mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| serum | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| xanthine + H2O + O2 | - |
Mus musculus | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | - |
Mus musculus BALB/c | urate + H2O2 | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | serum xanthine oxidase activity is correlated with serum uric acid levels, while no correlation is observed for liver xanthine oxidase activity. The serum uric acid levels in mice treated with the flavonoids genistein, apigenin, quercetin, rutin and astilbin are higher than control levels. No statistically significant difference in serum and liver xanthine oxidase activities between normal control mice and hyperuricemic mice | Mus musculus |
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