Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allopurinol | - |
Bos taurus | |
hydroxychavicol | i.e. 4-allyl-1,3-hydroxybenzene, a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle. Structure-activity relationships, the dihydroxyl group is required for the xanthine oxidase inhibitory activity, overview | Bos taurus | |
additional information | eugenol, methyleugenol, and dihydromethyleugenol are poor inhibitors | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
xanthine + O2 + H2O | Bos taurus | - |
urate + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
xanthine + O2 + H2O | - |
Bos taurus | urate + H2O2 | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0167 | - |
- |
Bos taurus | hydroxychavicol | |
0.0307 | - |
- |
Bos taurus | allopurinol |
General Information | Comment | Organism |
---|---|---|
metabolism | xanthine oxidase is a key enzyme in the purine metabolic pathway, catalysing the oxidation of hypoxanthine to uric acid | Bos taurus |