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Literature summary for 1.17.3.2 extracted from

  • Mostefai, H.A.; Agouni, A.; Carusio, N.; Mastronardi, M.L.; Heymes, C.; Henrion, D.; Andriantsitohaina, R.; Martinez, M.C.
    Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells (2008), J. Immunol., 180, 5028-5035.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
apoptotic lymphocyte microparticles microparticles are membrane vesicles released during cell activation and apoptosis, they activate reactive oxygen species production by xanthine oxidase in endothelial cells and aorta, inhibition of phosphoinositol 3-kinase enhances the activating effect, xanthine oxidase inhibitors reduce it, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells, overview ?
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?
xanthine + H2O + O2 Homo sapiens production of reactive oxygen species via superoxide radicals involved in endothelial dysfunction urate + H2O2
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Homo sapiens
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CCRF-CEM cell a lymphoid cell line Homo sapiens
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endothelial cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells, overview Homo sapiens ?
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?
xanthine + H2O + O2 production of reactive oxygen species via superoxide radicals involved in endothelial dysfunction Homo sapiens urate + H2O2
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?
xanthine + H2O + O2 production of superoxide radicals Homo sapiens urate + H2O2
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?