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Literature summary for 1.17.3.2 extracted from

  • Reigan, P.; Gbaj, A.; Stratford, I.J.; Bryce, R.A.; Freeman, S.
    Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors (2008), Eur. J. Med. Chem., 43, 1248-1260.
    View publication on PubMed
Search for more literature for 1.17.3.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0238
-
 6-amino-5-bromo-3H-pyrimidin-4-one
-
 Bos taurus
0.0298
-
 1H-pyrrolo[2,3-d]pyrimidin-2-ol substrate and inhibitor compound Bos taurus
0.0325
-
 6-amino-5-bromo-1H-pyrimidin-2-one
-
 Bos taurus
0.0444
-
 6-amino-5-bromopyrimidine
-
 Bos taurus
0.0451
-
 3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one substrate and inhibitor compound Bos taurus
0.0649
-
 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-3H-pyrimidin-4-one substrate and inhibitor compound Bos taurus
0.0672
-
 7H-pyrrolo[2,3-d]pyrimidine substrate and inhibitor compound Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + H2O + O2 Bos taurus
-
 urate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk buttermilk Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-3H-pyrimidin-4-one + H2O + O2
-
 Bos taurus ?
-
 ?
6-amino-5-bromo-1H-pyrimidin-2-one + H2O + O2
-
 Bos taurus ?
-
 ?
6-amino-5-bromo-3H-pyrimidin-4-one + H2O + O2
-
 Bos taurus ?
-
 ?
6-amino-5-bromopyrimidine + H2O + O2
-
 Bos taurus ?
-
 ?
7H-pyrrolo[2,3-d]pyrimidin-2(1H)-one + H2O + O2
-
 Bos taurus ?
-
 ?
7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one + H2O + O2
-
 Bos taurus ?
-
 ?
7H-pyrrolo[2,3-d]pyrimidine + H2O + O2
-
 Bos taurus ?
-
 ?
additional information 5-chloro-6-methyl-3H-pyrimidin-4-one is no substrate Bos taurus ?
-
 ?
xanthine + H2O + O2
-
 Bos taurus urate + H2O2
-
 ?