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Literature summary for 1.17.3.2 extracted from

  • Lin, H.C.; Tsai, S.H.; Chen, C.S.; Chang, Y.C.; Lee, C.M.; Lai, Z.Y.; Lin, C.M.
    Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities (2008), Biochem. Pharmacol., 75, 1416-1425.
    View publication on PubMed
Search for more literature for 1.17.3.2

Inhibitors

Inhibitors Comment Organism Structure
4-Hydroxycoumarin competitive inhibition and interaction with the molybdopterin region of the enzyme, structure-function relationship of coumarin derivatives in inhibition of the enzyme, structure-based computer-aided molecular modeling, overview Mus musculus
4-methylesculetin competitive inhibition and interaction with the molybdopterin region of the enzyme, structure-function relationship of coumarin derivatives in inhibition of the enzyme, structure-based computer-aided molecular modeling, overview Mus musculus
7-hydroxy-4-methylcoumarin low competitive inhibition and interaction with the molybdopterin region of the enzyme, structure-function relationship of coumarin derivatives in inhibition of the enzyme, structure-based computer-aided molecular modeling, overview Mus musculus
7-hydroxycoumarin low competitive inhibition and interaction with the molybdopterin region of the enzyme, structure-function relationship of coumarin derivatives in inhibition of the enzyme, structure-based computer-aided molecular modeling, overview Mus musculus
allopurinol strong competitive inhibition Mus musculus
esculetin strong, competitive inhibition and interaction with the molybdopterin region of the enzyme, structure-function relationship of coumarin derivatives in inhibition of the enzyme, structure-based computer-aided molecular modeling, overview Mus musculus
additional information coumarin and dihydrocoumarin are poor inhibitors, measurement of combined reactive oxygen species-scavenging and xanthine oxidase-inhibition activities, 3D modeling of the docking of coumarin derivatives on xanthine oxidase, overview Mus musculus
scopoletin low competitive inhibition and interaction with the molybdopterin region of the enzyme, structure-function relationship of coumarin derivatives in inhibition of the enzyme, structure-based computer-aided molecular modeling, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
xanthine + H2O + O2 Mus musculus production of superoxide radicals urate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Neuro-2a cell
-
 Mus musculus
-
neuroblastoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
xanthine + H2O + O2 production of superoxide radicals Mus musculus urate + H2O2
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
 pH 7.0, 37°C, versus xanthine Mus musculus allopurinol
0.0781
-
 pH 7.0, 37°C, versus xanthine Mus musculus 4-Hydroxycoumarin