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Literature summary for 1.17.3.2 extracted from
- Application of HPLC to study the kinetics of a branched bi-enzyme system consisting of hypoxanthine-guanine phosphoribosyltransferase and xanthine oxidase - an important biochemical system to evaluate the efficiency of the anticancer drug 6-mercaptopurine (2007), J. Chromatogr. B, 850, 7-14.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-mercaptopurine + 2 H2O + 2 O2 | Bos taurus | - |
6-thiouric acid + 2 H2O2 | - |
? |  |
| 6-mercaptopurine + 2 H2O + 2 O2 | Homo sapiens | an anticancer prodrug, no activation by xanthine oxidase but conversion to the inactive metabolite 6-thiouric acid, catabolism, overview | 6-thiouric acid + 2 H2O2 | - |
? | |
| xanthine + H2O + O2 | Homo sapiens | - |
urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | Bos taurus | - |
urate + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Bos taurus | - |
| JURKAT cell | - |
Homo sapiens | - |
| lymphocyte | - |
Homo sapiens | - |
| milk | - |
Bos taurus | - |
| plasma | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
rate of extracellular catabolism of 6-mercaptopurine by XOD | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-mercaptopurine + 2 H2O + 2 O2 | - |
Homo sapiens | 6-thiouric acid + 2 H2O2 | - |
? | |
| 6-mercaptopurine + 2 H2O + 2 O2 | - |
Bos taurus | 6-thiouric acid + 2 H2O2 | - |
? | |
| 6-mercaptopurine + 2 H2O + 2 O2 | an anticancer prodrug, no activation by xanthine oxidase but conversion to the inactive metabolite 6-thiouric acid, catabolism, overview | Homo sapiens | 6-thiouric acid + 2 H2O2 | - |
? | |
| additional information | evaluation of a HPLC detection method for enzyme reaction products, overview | Homo sapiens | ? | - |
? | |
| additional information | evaluation of a HPLC detection method for enzyme reaction products, overview | Bos taurus | ? | - |
? | |
| xanthine + H2O + O2 | - |
Homo sapiens | urate + H2O2 | - |
? | |
| xanthine + H2O + O2 | - |
Bos taurus | urate + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| XOD | - |
Homo sapiens |
| XOD | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
| 7.4 | - |
assay at | Bos taurus |
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Release 2023.1 (January 2023)
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