Literature summary for 1.17.3.2 extracted from

Rus, D.A.; Sastre, J.; Vina, J.; Pallardo, F.V.
Induction of mitochondrial xanthine oxidase activity during apoptosis in the rat mammary gland (2007), Front. Biosci., 12, 1184-1189.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	xanthine oxidase is necessary during the physiological involution of tissues	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mammary gland	after weaning, during the involution of the mammary gland, enzyme activity increases and high mitochondrial H2O2 production takes place. Inhibition of xanthine oxidase slows down the involution of the mammary gland due to the decrease in the number of apoptotic cells and prevents the production of H2O2 that occurs during apoptosis	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	xanthine oxidase is necessary during the physiological involution of tissues	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)