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Literature summary for 1.17.3.2 extracted from

  • Li, H.; Cui, H.; Liu, X.; Zweier, J.L.
    Xanthine oxidase catalyzes anaerobic transformation of organic nitrates to nitric oxide and nitrosothiols: characterization of this mechanism and the link between organic nitrate and guanylyl cyclase activation (2005), J. Biol. Chem., 280, 16594-16600.
    View publication on PubMed
Search for more literature for 1.17.3.2

Activating Compound

Activating Compound Comment Organism Structure
ascorbate in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction Bos taurus
L-cysteine in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction Bos taurus
thiol in absence of thiols or ascorbate, no NO generation is detected from xanthine oxidase mediated organic nitrate reduction Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.49
-
 glyceryl trinitrate xanthine as cosubstrate Bos taurus
1.64
-
 isosorbide dinitrate xanthine as cosubstrate Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
organic nitrate + NADH Bos taurus organic nitrite is the initial product in the process of xanthine oxidase mediated organic nitrate biotransformation and is the precursor of NO and nitrosothiols, serving as the link between organic nitrate and soluble guanylyl cyclase organic nitrite + NAD+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
milk
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glyceryl trinitrate + 2,3-dihydroxybenzaldehyde
-
 Bos taurus ?
-
 ?
glyceryl trinitrate + NADH
-
 Bos taurus ? + NAD+ + H2O further reaction of organic nitrite with thiols or ascorbate leads to generation of NO or nitrosothiols ?
glyceryl trinitrate + xanthine
-
 Bos taurus urate + ?
-
 ?
isosorbide dinitrate + 2,3-dihydroxybenzaldehyde
-
 Bos taurus ?
-
 ?
isosorbide dinitrate + NADH
-
 Bos taurus ? + NAD+ + H2O further reaction of organic nitrite with thiols or ascorbate leads to generation of NO or nitrosothiols ?
isosorbide dinitrate + xanthine
-
 Bos taurus urate + ?
-
 ?
organic nitrate + NADH organic nitrite is the initial product in the process of xanthine oxidase mediated organic nitrate biotransformation and is the precursor of NO and nitrosothiols, serving as the link between organic nitrate and soluble guanylyl cyclase Bos taurus organic nitrite + NAD+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
XO
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Bos taurus