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Literature summary for 1.17.1.8 extracted from

  • Kimura, K.; Goto, T.
    A new flavin enzyme catalyzing the reduction of dihydrodipicolinate in sporulating Bacillus subtilis. II. Kinetics and regulatory function (1975), J. Biochem., 77, 415-420.
    View publication on PubMed
Search for more literature for 1.17.1.8

Inhibitors

Inhibitors Comment Organism Structure
dipicolinate non-competitively versus dihydrodipicolinate, competitive versus NADPH; positive cooperativity Bacillus subtilis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.072
-
 NADPH
-
 Bacillus subtilis
0.77
-
 dihydrodipicolinate
-
 Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2,3-dihydrodipicolinate + NAD(P)H Bacillus subtilis
-
 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
2,3-dihydrodipicolinate + NAD(P)H Bacillus subtilis PCI 219
-
 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
 PCI 219
-
Bacillus subtilis PCI 219
-
 PCI 219
-

Reaction

Reaction Comment Organism Reaction ID
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+ mechanism Bacillus subtilis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-dihydrodipicolinate + NAD(P)H
-
 Bacillus subtilis 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?
2,3-dihydrodipicolinate + NAD(P)H
-
 Bacillus subtilis PCI 219 2,3,4,5-tetrahydrodipicolinate + NAD(P)+
-
 ?

Cofactor

Cofactor Comment Organism Structure
FMN
-
 Bacillus subtilis
NADPH
-
 Bacillus subtilis