Literature summary for 1.17.1.4 extracted from

Khobragade, C.N.; Bodade, R.G.; Shinde, M.S.; Jaju, D.R.; Bhosle, R.B.; Dawane, B.S.
Microbial and xanthine dehydrogenase inhibitory activity of some flavones (2008), J. Enzyme Inhib. Med. Chem., 23, 341-346.

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Inhibitors

Inhibitors	Comment	Organism	Structure
6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Fusarium verticillioides
6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	noncompetitive, Ki-value 0.0011 mg/ml	Gallus gallus
6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Microsporum canis
6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Penicillium chrysogenum
6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Micrnosporum cannis, Serratia marcescens, Staphylococcus aureus	Serratia marcescens
6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Staphylococcus aureus
6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Trichoderma viride
6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Fusarium verticillioides
6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	competitive, Ki-value 0.00022 mg/ml	Gallus gallus
6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Microsporum canis
6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Penicillium chrysogenum
6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Serratia marcescens
6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Staphylococcus aureus
6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one	broad spectrum antifungal activity against Trichoderma viridae, Penicillium chrysogenum, Fusarium moniliformae, Microsporum cannis, Serratia marcescens, Staphylococcus aureus	Trichoderma viride

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	Km-value is 0.0025 mg/ml xanthine	Gallus gallus
additional information	-	additional information	Km-value is 0.0025 mg/ml xanthine	Staphylococcus aureus
additional information	-	additional information	Km-value is 0.0025 mg/ml xanthine	Penicillium chrysogenum
additional information	-	additional information	Km-value is 0.0025 mg/ml xanthine	Serratia marcescens
additional information	-	additional information	Km-value is 0.0025 mg/ml xanthine	Trichoderma viride
additional information	-	additional information	Km-value is 0.0025 mg/ml xanthine	Fusarium verticillioides
additional information	-	additional information	Km-value is 0.0025 mg/ml xanthine	Microsporum canis

Organism

Organism	UniProt	Comment	Textmining
Fusarium verticillioides	-	-	-
Gallus gallus	-	-	-
Microsporum canis	-	-	-
Penicillium chrysogenum	-	-	-
Serratia marcescens	-	-	-
Staphylococcus aureus	-	-	-
Trichoderma viride	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Gallus gallus	-
liver	-	Staphylococcus aureus	-
liver	-	Penicillium chrysogenum	-
liver	-	Serratia marcescens	-
liver	-	Trichoderma viride	-
liver	-	Fusarium verticillioides	-
liver	-	Microsporum canis	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.22	-	pH 7.5, 37°C	Gallus gallus
0.22	-	pH 7.5, 37°C	Staphylococcus aureus
0.22	-	pH 7.5, 37°C	Penicillium chrysogenum
0.22	-	pH 7.5, 37°C	Serratia marcescens
0.22	-	pH 7.5, 37°C	Trichoderma viride
0.22	-	pH 7.5, 37°C	Fusarium verticillioides
0.22	-	pH 7.5, 37°C	Microsporum canis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
xanthine + NAD+ + H2O	-	Gallus gallus	urate + NADH	-	?
xanthine + NAD+ + H2O	-	Staphylococcus aureus	urate + NADH	-	?
xanthine + NAD+ + H2O	-	Penicillium chrysogenum	urate + NADH	-	?
xanthine + NAD+ + H2O	-	Serratia marcescens	urate + NADH	-	?
xanthine + NAD+ + H2O	-	Trichoderma viride	urate + NADH	-	?
xanthine + NAD+ + H2O	-	Fusarium verticillioides	urate + NADH	-	?
xanthine + NAD+ + H2O	-	Microsporum canis	urate + NADH	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
40	-	-	Gallus gallus
40	-	-	Staphylococcus aureus
40	-	-	Penicillium chrysogenum
40	-	-	Serratia marcescens
40	-	-	Trichoderma viride
40	-	-	Fusarium verticillioides
40	-	-	Microsporum canis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	-	Gallus gallus
7.5	-	-	Staphylococcus aureus
7.5	-	-	Penicillium chrysogenum
7.5	-	-	Serratia marcescens
7.5	-	-	Trichoderma viride
7.5	-	-	Fusarium verticillioides
7.5	-	-	Microsporum canis

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	6-chloro-2-[3-(4-hydroxyphenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one, Ki-value 0.0011 mg/ml, 6-chloro-7-methyl-2-[3-(4-chlorophenyl)-1-phenyl-1-H-pyrazol-4-yl]-chromen-4-one, Ki-value 0.00022 mg/ml, respectively	Gallus gallus

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Release 2023.1 (January 2023)