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Literature summary for 1.17.1.4 extracted from

  • Maia, L.; Duarte, R.O.; Ponces-Freire, A.; Moura, J.J.; Mira, L.
    NADH oxidase activity of rat and human liver xanthine oxidoreductase: potential role in superoxide production (2007), J. Biol. Inorg. Chem., 12, 777-787.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
liver the dehydrogenase form of liver xanthine oxidoreduxtase is intrinsically more efficient at generating superoxide anion radicals than the oxidase form, independently of the reducing substrat Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + O2 + H+ xanthine dehydrogenase catalyzes NADH oxidation leading to the formation of one O2- radical and half a H2O2 molecule, at rates three times those observed for xanthine oxidase. NADH efficiently oxidizes xanthine dehydrogenase, but only a great excess of NADH reduces xanthine oxidase Rattus norvegicus NAD+ + O2- + H2O2
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