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Literature summary for 1.16.3.1 extracted from
- Functional link between ferroxidase activity of ceruloplasmin and protective effect of apo-lactoferrin studying rats kept on a silver chloride diet (2016), Biometals, 29, 691-704 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| lactoferrin | enhances the ferroxidase activity of ceruloplasmin | Rattus norvegicus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| purified recombinant E57A/E136A/D140A mutant ferritin, X-ray diffraction structure determination and analysis | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ag+ | in ceruloplasmin, purified from sera of Ag-rats, two copper ions are substituted with two silver ions | Rattus norvegicus |  |
| NaN3 | efficient inhibition | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | dependent on | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 Fe(II) + 4 H+ + O2 | Rattus norvegicus | - |
4 Fe(III) + 2 H2O | - |
? | |
| 4 Fe(II) + 4 H+ + O2 | Rattus norvegicus Wistar | - |
4 Fe(III) + 2 H2O | - |
? | |
| additional information | Rattus norvegicus | both in vitro and in vivo ceruloplasmin is able to form the specific complex with lactoferrin, the cationic transferrin of exocrine secretions and secretory granules of neutrophils | ? | - |
? | |
| additional information | Rattus norvegicus Wistar | both in vitro and in vivo ceruloplasmin is able to form the specific complex with lactoferrin, the cationic transferrin of exocrine secretions and secretory granules of neutrophils | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P13635 | - |
- |
| Rattus norvegicus Wistar | P13635 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme from rat blood serum of untreated and Ag-treated animals by ion exchange chromatography and neomycin affinity chromatography | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood serum | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 Fe(II) + 4 H+ + O2 | - |
Rattus norvegicus | 4 Fe(III) + 2 H2O | - |
? | |
| 4 Fe(II) + 4 H+ + O2 | - |
Rattus norvegicus Wistar | 4 Fe(III) + 2 H2O | - |
? | |
| additional information | both in vitro and in vivo ceruloplasmin is able to form the specific complex with lactoferrin, the cationic transferrin of exocrine secretions and secretory granules of neutrophils | Rattus norvegicus | ? | - |
? | |
| additional information | both in vitro and in vivo ceruloplasmin is able to form the specific complex with lactoferrin, the cationic transferrin of exocrine secretions and secretory granules of neutrophils | Rattus norvegicus Wistar | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ceruloplasmin | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | - |
assay at | Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | HIF-1a and its homologue HIF-2a enhance the transcription of ceruloplasmin | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | strongly pronounced argyrosis caused by adding AgCl to the feed of laboratory rats efficiently mimics the deficiency of ceruloplasmin ferroxidase activity. The deficiency of ceruloplasmin ferroxidase activity in Ag-fed rats affects the iron content in serum, though does not prevent the recovery of hemoglobin level accompanied by exhaustion of iron caches in liver and spleen. When apolactoferrin (apo-LF) is administered to Ag-rats suffering from either post-hemorrhagic or hemolytic anemia, both hemoglobin and serum iron are restored more rapidly than in the control animals. Saturation of apo-LF with iron, provided by active ceruloplasmin, can strongly affect its protective capacity. Phenotype, overview | Rattus norvegicus |
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