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Literature summary for 1.16.1.8 extracted from

  • Garcia-Minguillan, C.J.; Fernandez-Ballart, J.D.; Ceruelo, S.; Rios, L.; Bueno, O.; Berrocal-Zaragoza, M.I.; Molloy, A.M.; Ueland, P.M.; Meyer, K.; Murphy, M.M.
    Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine (2014), Genes Nutr., 9, 435 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene MTRR, genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information common naturally occuring polymorphisms are MTRR 66A>G or MTRR 524C>T, which affect the enzyme activity. Effects of the MTRR genotype on human status with respect to vitmain B6, plasma folate, homocysteine, and plasma cobalamine levels, modeling, detailed overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine Homo sapiens
-
2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBK8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 [methionine synthase]-cob(II)alamin + NADPH + H+ + 2 S-adenosyl-L-methionine
-
Homo sapiens 2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP+
-
?

Synonyms

Synonyms Comment Organism
Methionine synthase reductase
-
Homo sapiens
MTRR
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD the C-terminal domain of MTRR binds FAD Homo sapiens
FMN the N-terminal domain of MTRR binds flavin mononucleotide Homo sapiens
additional information a riboflavin-dependent enzyme Homo sapiens
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme enzyme plays a key role in homocysteine metabolism Homo sapiens
additional information effects of the MTRR genotype on human status with respect to vitmain B6, plasma folate, homocysteine, and plasma cobalamine levels, modeling, detailed overview Homo sapiens
physiological function roles of methionine synthase, MS, and methylenetetrahydrofolate reductase, MTHFR, and methionine synthase reductase, MTRR, in the folate cycle and homocysteine remethylation, overview Homo sapiens